Immunotropic effects of nitrogenous metabolites in healthy humans

Background. We have previously shown that nitrogenous metabolites immunomodulatory effects, both in healthy rats and humans exposed to pathogenic influences. The purpose of this study is their immunotropic activity clinically people. Materials Methods. object observation were 27 men (aged 24-63 ys) 14 women (33-62 ys). plasma levels the parameters immunity twice with an interval 5 days was performed. Results. Judging by multiple correlation coefficient uric acid exhibits maximal (R=0,665), followed creatinine (R=0,596) urea (R=0,541), closes constellation bilirubin, conjugated bilirubin predominating over unconjugated (0,539 vs 0,484). Nitrogenous together upregulate level blood B-lymphocytes, CIC, IgG, IL-1, eosinophils monocytes, as well most phagocytosis neutrophils Staph. aureus E. coli. Instead, they downregulate aureus, relative content rod-shaped neutrophils, lymphocytes general NK-, T active 0-Lymphocytes particular. Downregulation reflects upregulation receptor expression, apparently CD22. Conclusion. exhibit humans, patients.